Kinetic and Crystallographic Studies on Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in Complex with Iodoacetate

Title: Kinetic and Crystallographic Studies on Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in Complex with Iodoacetate

Volume: 6 Issue: 3

Author(s): Rafael V.C. Guido, Tatiane L. Balliano, Adriano D. Andricopulo and Glaucius Oliva

Affiliation:

Keywords: Parasitic infections, Trypanosoma cruzi, Inhibitors, Enzyme, Glyceraldehyde-3-phosphate dehydrogenase, X-ray crystallography

Abstract: Kinetic and crystallographic studies on the formation of the complex between iodoacetate and the enzyme glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi were conducted in order to investigate the mechanistic and structural basis underlying enzyme inactivation. The crystallographic complex reveal important structural features useful for the design of novel inhibitors.

Cite this article as:

Guido V.C. Rafael, Balliano L. Tatiane, Andricopulo D. Adriano and Oliva Glaucius, Kinetic and Crystallographic Studies on Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in Complex with Iodoacetate, Letters in Drug Design & Discovery 2009; 6 (3) . https://dx.doi.org/10.2174/157018009787847774