Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Kinetic and Crystallographic Studies on Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in Complex with Iodoacetate

Author(s): Rafael V.C. Guido, Tatiane L. Balliano, Adriano D. Andricopulo, Glaucius Oliva.

Abstract:

Kinetic and crystallographic studies on the formation of the complex between iodoacetate and the enzyme glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi were conducted in order to investigate the mechanistic and structural basis underlying enzyme inactivation. The crystallographic complex reveal important structural features useful for the design of novel inhibitors.

Keywords: Parasitic infections, Trypanosoma cruzi, Inhibitors, Enzyme, Glyceraldehyde-3-phosphate dehydrogenase, X-ray crystallography

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2009
Page: [210 - 214]
Pages: 5
DOI: 10.2174/157018009787847774
Price: $58