Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Hydroxamic Acids Designed as Inhibitors of Urease

Author(s): Thalita G. Barros, John S. Williamson, O. A.C. Antunes, Estela M.F. Muri.

Abstract:

Urease is an enzyme responsible for the hydrolysis of urea into ammonia and carbamate. Humans infected by urease are exposed to a risk of chronic gastritis or cancer. Urease inhibitors have attracted a great deal of attention for their potential as new anti-ulcer drugs. Here, we describe the synthesis of series of hydroxamic acid compounds designed as inhibitors of urease.

Keywords: Hydroxamic acids, Urease, Gastritis, Inhibitors

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2009
Page: [186 - 192]
Pages: 7
DOI: 10.2174/157018009787847783
Price: $58