Hydroxamic Acids Designed as Inhibitors of Urease
Thalita G. Barros,
John S. Williamson,
O. A.C. Antunes,
Estela M.F. Muri.
Urease is an enzyme responsible for the hydrolysis of urea into ammonia and carbamate. Humans infected by urease are exposed to a risk of chronic gastritis or cancer. Urease inhibitors have attracted a great deal of attention for their potential as new anti-ulcer drugs. Here, we describe the synthesis of series of hydroxamic acid compounds designed as inhibitors of urease.
Keywords: Hydroxamic acids, Urease, Gastritis, Inhibitors
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