Synthesis and Biological Evaluation of Aromatase Inhibitors

Author(s): Jinpei Zhou, Huibin Zhang, Hai Qian, Liang Lin, Wenlong Huang, Shuaijian Ni.

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 3 , 2009

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Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. In an effort to develop new therapies to treat breast cancer, a series of 1-phenethyl-1H-[1,2,4]triazole derivatives (6a-6h) were synthesized and evaluated for their efficacy as aromatase inhibitors. Biological tests suggest that these compounds exhibit mild to moderate inhibitory activity to aromatase.

Keywords: Estrogen, Aromatase inhibitor, Anticancer, Nonsteroidal, Synthesis, 1H-[1,2,4]triazole

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Article Details

Year: 2009
Page: [181 - 185]
Pages: 5
DOI: 10.2174/157018009787847846
Price: $65

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