Synthesis and Biological Evaluation of Aromatase Inhibitors

Title: Synthesis and Biological Evaluation of Aromatase Inhibitors

Volume: 6 Issue: 3

Author(s): Jinpei Zhou, Huibin Zhang, Hai Qian, Liang Lin, Wenlong Huang and Shuaijian Ni

Affiliation:

Keywords: Estrogen, Aromatase inhibitor, Anticancer, Nonsteroidal, Synthesis, 1H-[1,2,4]triazole

Abstract: Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. In an effort to develop new therapies to treat breast cancer, a series of 1-phenethyl-1H-[1,2,4]triazole derivatives (6a-6h) were synthesized and evaluated for their efficacy as aromatase inhibitors. Biological tests suggest that these compounds exhibit mild to moderate inhibitory activity to aromatase.

Cite this article as:

Zhou Jinpei, Zhang Huibin, Qian Hai, Lin Liang, Huang Wenlong and Ni Shuaijian, Synthesis and Biological Evaluation of Aromatase Inhibitors, Letters in Drug Design & Discovery 2009; 6 (3) . https://dx.doi.org/10.2174/157018009787847846