Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Anti HIV-1 Agents 2. Discovery of Dibenzofurans as New HIV-1 Inhibitors In Vitro

Author(s): Ling-Ling Fan, Wu-Qing Liu, Hui Xu, Liu-Meng Yang, Min Lv, Yong-Tang Zheng.

Abstract:

Ten dibenzofurans were synthesized and evaluated as human immunodeficiency virus (HIV)-1 inhibitors in vitro for the first time. Among these compounds, compounds 1, 6, 7 and 8 demonstrated significant anti-HIV-1 activity. Especially compound 1 showed the highest anti-HIV-1 activity with TI value larger than 16.18. Meanwhile, some structureactivity relationships were also observed and will provide a new lead for design and discovery of more potent dibenzofurans as new HIV-1 inhibitors.

Keywords: Dibenzofuran, Human immunodeficiency virus, Inhibitor, Synthesis

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2009
Page: [178 - 180]
Pages: 3
DOI: 10.2174/157018009787847873
Price: $58