Synthesis of Novel Benzoquinones with Anti-Inflammatory Activity
Elias A. Couladouros.
Some novel benzoquinones and their dimethoxy chemical precursors were synthesized based on shikonin structural features. The quinone functionality showed strong .OH radical scavenging, whereas benzoquinones with an α- hydroxy-containing saturated side chain exhibited increased soybean lipoxygenase inhibition. Compounds 5, 5b and 7 were superior to indomethacin in vivo in the carrageenin-induced rat paw edema inhibition.
Keywords: Shikonin, Inflammation, Psoriasis, LOX, Radical scavengers, Benzoquinones
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