Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis of Novel Benzoquinones with Anti-Inflammatory Activity

Author(s): Marina Sagnou, Alexandros Strongilos, Dimitra Hadjipavlou-Litina, Elias A. Couladouros.

Abstract:

Some novel benzoquinones and their dimethoxy chemical precursors were synthesized based on shikonin structural features. The quinone functionality showed strong .OH radical scavenging, whereas benzoquinones with an α- hydroxy-containing saturated side chain exhibited increased soybean lipoxygenase inhibition. Compounds 5, 5b and 7 were superior to indomethacin in vivo in the carrageenin-induced rat paw edema inhibition.

Keywords: Shikonin, Inflammation, Psoriasis, LOX, Radical scavengers, Benzoquinones

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2009
Page: [172 - 177]
Pages: 6
DOI: 10.2174/157018009787847792
Price: $58