Central Nervous System Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Central Nervous System Agents)

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Anti-Inflammatory Effects of Antidepressants: Possibilities for Preventives Against Alzheimers Disease

Author(s): Sadayuki Hashioka, Patrick L. McGeer, Akira Monji and Shigenobu Kanba

Affiliation: Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, B.C., V6T 1Z3, Canada.

Keywords: Antidepressants, major depression, Alzheimer's disease, inflammation, cytokines, microglia

Abstract:

Increasing evidence of pro-inflammatory mediator expression in major depressions indicate that inflammatory changes may play a role. If this is true, the efficacy of antidepressants may be partially attributable to suppression of inflammation. Various types of antidepressants can suppress serum and plasma levels of pro-inflammatory mediators in patients with major depression. Therefore they can inhibit the production of pro-inflammatory mediators by immune cells. These include glial cells, which are the main sources and targets of cytokines in the brain. This review summarizes the evidence showing that antidepressants have an anti-inflammatory potential. The putative mechanisms are also discussed. Because of the anti-inflammatory effects of antidepressants, they might also act as preventives for neurodegenerative dementias including Alzheimers disease, where the pathogenesis involves chronic inflammation associated with activated microglia.

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Article Details

VOLUME: 9
ISSUE: 1
Page: [12 - 19]
Pages: 8
DOI: 10.2174/187152409787601897