Endocrine, Metabolic & Immune Disorders-Drug Targets

(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Emilio Jirillo  
Universitá degli Studi di Bari
Dipartimento di Clinica Medica
Immunologia e Malattie Infettive
Sezione di Microbiologia e Immunologia
Piazza Giulio Cesare-Policlinico
Bari
Italy

Back

Glucans as Biological Response Modifiers

Author(s): M. Novak and V. Vetvicka

Affiliation: University of Louisville, Department of Pathology, 511 S. Floyd, MDR Bldg., Rm. 224, Louisville, KY 40202, USA.

Keywords: Glucan, saccharides, immune system, macrophages, CR3, yeast

Abstract:

β-D-glucans belong to a group of natural, physiologically active compounds, generally called biological response modifiers. Glucans represent highly conserved structural components of cell walls in yeast, fungi, or seaweed. Despite long history of research, the exact mechanisms of glucan action remain unsolved. The present review starts with the history of glucans. Next, the detailed information about the possible glucan sources is followed by a description of the mechanisms of action. Physiological functions of glucan suggest the possible use of glucans not only as non-specific immunomodulator, but also as its possible future use as a drug.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 9
ISSUE: 1
Page: [67 - 75]
Pages: 9
DOI: 10.2174/187153009787582423