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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

3-Aminosterol Compounds as a New Class of Anti-Malarial Agents against Chloroquine-Susceptible and -Resistant Plasmodium falciparum

Author(s): Chanaz Salmi, Celine Loncle, Nicolas Vidal, Christophe Rogier, Yves Letourneux, Bruno Pradines and Jean Michel Brunel

Volume 6, Issue 2, 2009

Page: [163 - 166] Pages: 4

DOI: 10.2174/157018009787582633

Price: $65

Abstract

A series of 3-amino- and polyaminosterol analogues of squalamine and trodusquemine were evaluated for their in vitro antimalarial properties against chloroquine-susceptible and -resistant Plasmodium falciparum. These derivatives were designed possessing a good therapeutic index compared to chloroquine with IC50 varying from 2 to 22 μM. These compounds as well as the underlying design rationale may find usefulness in the discovery and development of new antimalarial drugs.

Keywords: Squalamine, Trodusquemine, Aminosterol derivatives, Antimalarial activity


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