Synthesis and Antiproliferative Activity of Coumarin-Estrogen Conjugates against Breast Cancer Cell Lines

Author(s): Musiliyu A. Musa, M. Omar F. Khan, John S. Cooperwood.

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 2 , 2009

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Abstract:

The syntheses and cytotoxic activity of coumarin-estrogen conjugates are described. In vitro results indicated that conjugates 10, 11 and 13 show growth inhibitory activities at 5-dose concentration (100, 10, 1, 0.1, 0.01 μM) against the following NCI-7- human breast cancer cell lines: BT-549, HS 578T, MCF 7, MDA-MB-231/ATCC, MDA-MB-435, NCI/ADR-RES, and thus serve as new leads for further development of antibreast cancer agent.

Keywords: Coumarin, 17β-estradiol, Conjugates, Cytotoxicity, Antiproliferative activity and Breast cancer

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2009
Page: [133 - 138]
Pages: 6
DOI: 10.2174/157018009787582624
Price: $58

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