A Novel Synthesis Method of Apogossypolone and its Antitumor Activity

Author(s): Yonghua Zhan, Guangfeng Jia.

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 2 , 2009

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Abstract:

A derivative of gossypol, 6,7,6,7-Tetrahydroxy-5,5-diisopropyl-3,3-dimethyl-[2,2] binaphthalenyl- 1,4,1,4-tetraone (Apogossypolone, ApoG2), has been synthesized from gossypol acetic acid. Its structure was identified by IR, NMR, MS spectrum and cancer cells in vitro growth inhibition experiments were performed. The results indicate that apogossypolone exerts strong in vitro growth inhibition in human prostate cancer cells, representing a promising cancer therapeutic.

Keywords: Gossypol, Apogossypolone, Synthesis, In vitro growth inhibition, Proteins

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2009
Page: [129 - 132]
Pages: 4
DOI: 10.2174/157018009787582589
Price: $58

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