Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Physical Stability of PLGA Microparticles for DNA Encapsulation

Author(s): Itziar Migueliz, Sonsoles Diez, Gemma Navarro, Conchita Tros de ILarduya.

Abstract:

In this study, we have evaluated the stability of poly (D,L-lactide-co-glycolide) (PLGA)-DNA microparticles prepared by using several types of polymers (RG502, RG503, RG504, RG502H, and RG752). Particles were characterised in terms of size, zeta potential, morphology and structural integrity just immediately after preparation, after lyophilisation and after 2 years of storage at -20°C. DNA has been demonstrated to be sufficiently stable for efficient incorporation into PLGA microparticles at least for 2 years after lyophilisation.

Keywords: Stability, Poly (D,L-lactic-co-glycolic acid) (PLGA), Microparticles, Gene delivery, Biodegradable polymers, Microencapsulation

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2009
Page: [125 - 128]
Pages: 4
DOI: 10.2174/157018009787582679
Price: $58