Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis of Substituted 1H-Pyrrol-2(5H)-ones and 2(5H)-Furanones as Inhibitors of P. aeruginosa Biofilm

Author(s): Jia-Liang Guo, Bing-Zhou Li, Wei-Min Chen, Ping-Hua Sun, Yuqiang Wang.

Abstract:

A series of substituted 1H-pyrrol-2(5H)-ones and three 2(5H)-furanones were designed and chemically synthesized. Their inhibitory activities against P. aeruginosa biofilm formation were investigated by using atomic force microscope (AFM) and scanning electron microscope (SEM) technologies. Brominated 1H-pyrrol-2(5H)-ones were found to significantly inhibit P. aeruginosa biofilm formation.

Keywords: Quorum sensing, Biofilm, 2(5H)-Furanones, 1H-Pyrrol-2(5H)-one, Synthesis, P. aeruginosa

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Article Details

VOLUME: 6
ISSUE: 2
Year: 2009
Page: [107 - 113]
Pages: 7
DOI: 10.2174/157018009787582642
Price: $58