Novel N-Substituted Thiazolidinones as Proton Pump Inhibitors and Potent Anti-Ulcer Agents: SAR Study
B. M. Srikanta,
C.S. Ananda Kumar,
N. R. Thimmegowda,
S. R. Ranganatha,
Shylaja M. Dharmesh,
K. S. Rangappa.
A series of N-substituted thiazolidinone derivatives 5(a-j) was synthesized in good yield. All the compounds were screened for their in vitro H+, K+- ATPase inhibitory activity. The structures of the synthesized compounds were confirmed by the spectral data. Compounds 5d, 5e, 5f and 5c showed potential H+, K+- ATPase blocking activities, when compared to standard drug Lansoprazole. Structure-activity relationship studies, with various chemical groups, revealed that position and nature of the substitution on the N-thiazolidinones are crucial for H+, K+- ATPase inhibitory activity.
Keywords: Thiazolidinone, 5-Formyl-2-methoxybenzoic acid, Alkyl halides, Anti-ulcer, Peptic ulcer, H+, K+- ATPase enzyme
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