Derivatives of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic Acid as Novel Fibrinogen Receptor Antagonists

Author(s): Olga L. Malovichko , Andrei A. Krysko , Tatyana A. Kabanova , Sergei A. Andronati , Vladimir I. Grishkovets , Vadim V. Kachala , Denis A. Panov .

Journal Name: Medicinal Chemistry

Volume 5 , Issue 2 , 2009

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It has been proposed a novel method for obtaining of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid as Argmimetic within the framework of search for novel fibrinogen receptor antagonists. New αIIbβ3 antagonists were prepared on a base of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid. Their high antiaggregatory activities in a human platelet rich plasma and ability to block FITC-Fg binding to αIIbβ3 on washed human platelets were estimated.

Keywords: fibrinogen receptor antagonists, αIIbβ3, RGD mimetics, 1,2,3,4-tetrahydroisoquinoline, platelet aggregation

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Article Details

Year: 2009
Page: [158 - 164]
Pages: 7
DOI: 10.2174/157340609787582909
Price: $58

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