Physiological and Pathophysiological Functions of SIRT1

Author(s): M. Wojcik , K. Mac-Marcjanek , L. A. Wozniak .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 3 , 2009

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Abstract:

The human SIRT1 is a nuclear enzyme from the class III histone deacetylases (HDACs) which is widely distributed in mammalian tissues. A variety of SIRT1 substrates hints that this protein is involved in the regulation of diverse biological processes, including cell survival, apoptosis, gluconeogenesis, adipogenesis, lipolysis, stress resistance, muscle differentiation, and insulin secretion. This review emphasizes catalytic properties of SIRT1 and its role in apoptosis, insulin pathway, and neuron survival.

Keywords: FOXO factors, NAD+-dependent deacetylase, p53, resveratrol, Sir2, SIRT1

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2009
Page: [386 - 394]
Pages: 9
DOI: 10.2174/1389557510909030386
Price: $58

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