Lysophospholipids: Their Generation, Physiological Role and Detection. Are They Important Disease Markers?

Author(s): Beate Fuchs, Jurgen Schiller.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 3 , 2009

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Abstract:

The concentration of lysophospholipids (LPL) increases under pathological conditions and, thus, LPL attract diagnostic and pharmacological interest. LPL are particularly interesting because they possess pro- and anti-inflammatory properties and can be generated by phospholipases and reactive oxygen species (ROS). This review provides an overview of the mechanisms by which LPL are generated and how they can be determined. The effects of LPL as signaling molecules and their roles in different pathologies are discussed. The focus will be on lysophosphatidylcholine (LPC).

Keywords: Lysophospholipids, Phospholipids, Lysophosphatidylcholine, Phospholipase, Reactive Oxygen Species, Inflammation, Disease Markers, Signaling Molecules

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2009
Page: [368 - 378]
Pages: 11
DOI: 10.2174/1389557510909030368
Price: $58

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