Oligomerization of the Heptahelical G Protein Coupling Receptors: A Case for Association Using Transmembrane Helices (Supplimentry Material)

Author(s): M. S. Parker , R. Sah , E. A. Park , T. Sweatman , A. Balasubramaniam , F. R. Sallee , S. L. Parker .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 3 , 2009

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Abstract:

The heptahelical G protein coupling receptors oligomerize extensively via transmembrane domains, in association with heterotrimeric G proteins. This provides higher affinity for agonists, conformational stability necessary for signal transduction, and protection from intracellular proteinases. The oligomerization is relevant to organismic pathophysiology and could be targeted by natural or modified agonists. For Supplement material, please see the online version of the article.

Keywords: Rhodopsin-like receptor, receptor homodimer, receptor heterodimer, receptor oligomer, signal transduction

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2009
Page: [329 - 339]
Pages: 11
DOI: 10.2174/1389557510909030329
Price: $58

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