The Role of WNT in Rheumatoid Arthritis and its Therapeutic Implication

Author(s): Kazushi Imai, Tadashige Chiba, Genta Maeda, Masako Morikawa.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 3 , 2009

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Abstract:

Rheumatoid arthritis (RA) is a systematic inflammatory and intractable disease, which progressively affects multiple joints. Recent findings strongly suggest a key role of WNT signaling in the disease initiation and progression. In this review, we discuss the role and possibility of treatment by targeting WNT signaling.

Keywords: WNT, rheumatoid arthritis, FRP, β-catenin, synovium, matrix metalloproteinase

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2009
Page: [318 - 323]
Pages: 6
DOI: 10.2174/1389557510909030318
Price: $58

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