P-gp Transporter and its Role in Neurodegenerative Diseases

Author(s): Simona Rapposelli, Maria Digiacomo, Aldo Balsamo.

Journal Name: Current Topics in Medicinal Chemistry

Volume 9 , Issue 2 , 2009

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Abstract:

This paper describes an overview of recent insights concerning some socially relevant neurodegenerative diseases such as Alzheimers (AD), Parkinsons (PD), Huntingtons (HD) and Creutzfeldt-Jakobs (CJD) diseases, amyotrophic lateral sclerosis (ALS) and epilepsy. For each pathological state, the direct and/or indirect involvement of Pglycoprotein (P-gp) efflux transport is underlined. On this basis, P-gp still represents an innovative target which can offer new tools for the development of more effective and preventive therapeutic strategies for neurodegenerative disorders. For each of them, therefore, a possible use of drugs affecting P-gp transport activity has been suggested.

Keywords: P-glycoprotein, Neurodegenerative disorder, Epilepsy, Alzheimer, Parkinson, Hungtington, ALS

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2009
Page: [209 - 217]
Pages: 9
DOI: 10.2174/156802609787521544
Price: $58

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