C-Alkoxycarbonyl Nitrones: Building Blocks for the Synthesis of Butenolides, Lactams and Modified Nucleosides

Title: C-Alkoxycarbonyl Nitrones: Building Blocks for the Synthesis of Butenolides, Lactams and Modified Nucleosides

Volume: 2 Issue: 1

Author(s): G. Romeo, D. Iannazzo, A. Piperno, R. Romeo, A. Corsaro, A. Rescifina and U. Chiacchio

Affiliation:

Keywords: nitrones, butenolides, lactams, modified nucleosides

Abstract: Elaboration of isoxazolidines derived from the 1,3-dipolar cycloaddition of C-alkoxycarbonyl nitrones to suitably substituted alkenes leads to the development of new synthetic methodologies for the preparation of a wide range of natural products and derivatives including lactones, lactams and complex nucleosides. The insertion of a chiral centre in position β, with respect to nitrone functionality, or the presence of a chiral auxiliary at the nitrogen atom have allowed the enantioselective synthesis of the same compounds.

Cite this article as:

Romeo G., Iannazzo D., Piperno A., Romeo R., Corsaro A., Rescifina A. and Chiacchio U., C-Alkoxycarbonyl Nitrones: Building Blocks for the Synthesis of Butenolides, Lactams and Modified Nucleosides, Mini-Reviews in Organic Chemistry 2005; 2 (1) . https://dx.doi.org/10.2174/1570193052774144