Login

Journal Image
Current Organic Synthesis
ISSN (Print): 1570-1794
ISSN (Online): 1875-6271
VOLUME: 6
ISSUE: 1
DOI: 10.2174/157017909787314858









Enantioselective Enzyme-Catalysed Synthesis of Cyanohydrins

img
Author(s): Jarle Holt and Ulf Hanefeld
Pages 15-37 (23)
Abstract:
Cyanohydrins are valuable intermediates in organic synthesis. They enable an extensive chemistry that can be implemented starting either from the nitrile or from the hydroxy functionality. A number of challenges relevant to the enzyme-catalysed synthesis of chiral cyanohydrins have been addressed in recent years. In this review we will discuss three topics: (1) The enantioselective synthesis of cyanohydrins catalysed by Hydroxynitrile Lyases (Oxynitrilases); (2) The preparation of enantiopure cyanohydrins catalysed by hydrolases/ lipases via (dynamic) kinetic resolutions and (3) the (in situ) conversion of the enantiopure cyanohydrins, extending the use of cyanohydrins as building blocks in organic synthesis.
Keywords:
Cyanohydrin, hydroxynitrile lyase, oxynitrilase, lipase, kinetic resolution, dynamic kinetic resolution
Affiliation:
Gebouw voor Scheikunde, Afdeling Biotechnologie, Technische Universiteit Delft, Julianalaan 136, 2628 BL Delft, The Netherlands.