Enantioselective Enzyme-Catalysed Synthesis of Cyanohydrins

Author(s): Jarle Holt, Ulf Hanefeld.

Journal Name: Current Organic Synthesis

Volume 6 , Issue 1 , 2009

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Abstract:

Cyanohydrins are valuable intermediates in organic synthesis. They enable an extensive chemistry that can be implemented starting either from the nitrile or from the hydroxy functionality. A number of challenges relevant to the enzyme-catalysed synthesis of chiral cyanohydrins have been addressed in recent years. In this review we will discuss three topics: (1) The enantioselective synthesis of cyanohydrins catalysed by Hydroxynitrile Lyases (Oxynitrilases); (2) The preparation of enantiopure cyanohydrins catalysed by hydrolases/ lipases via (dynamic) kinetic resolutions and (3) the (in situ) conversion of the enantiopure cyanohydrins, extending the use of cyanohydrins as building blocks in organic synthesis.

Keywords: Cyanohydrin, hydroxynitrile lyase, oxynitrilase, lipase, kinetic resolution, dynamic kinetic resolution

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Article Details

VOLUME: 6
ISSUE: 1
Year: 2009
Page: [15 - 37]
Pages: 23
DOI: 10.2174/157017909787314858

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