Antiglucocorticoids, Neurogenesis and Depression

Author(s): Carlos P. Fitzsimons , Lenneke W.A. van Hooijdonk , John A. Morrow , Bernard W.M.M. Peeters , Niall Hamilton , Mark Craighead , Erno Vreugdenhil .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 2 , 2009

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Abstract:

Recent evidence suggests that antiglucocorticoids, like conventional antidepressants, may recover depressive symptoms by boosting hippocampal neurogenesis. Here, we explore several possible antiglucocorticoid-based antidepressive therapeutic strategies. Firstly, we review specific glucocorticoid receptor/antagonist interactions. Secondly, we discuss a potential new therapeutic target, doublecortin-like kinase, which regulates glucocorticoid signaling in neuronal progenitor cells.

Keywords: Stress, glucocorticoid receptor, dentate gyrus, hippocampus, neurogenesis, antidepressants, depression, doublecortin- like kinase, anti-glucocorticoids

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2009
Page: [249 - 264]
Pages: 16
DOI: 10.2174/138955709787316001
Price: $58

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