Molecular Modeling Studies of ABC Transporters Involved in Multidrug Resistance

Author(s): Aina Westrheim Ravna, Georg Sager.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 2 , 2009

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Abstract:

Multidrug resistance (MDR) is a limitation to cancer chemotherapy, antibiotic treatment and HIV medication. Molecular models of the ABC transporters ABCB1 (P-glycoprotein), ABCC4 (multidrug resistance protein 4 (MRP4)) and ABCC5 (MRP5), which are involved in MDR, may aid in the development of drugs inhibiting anticancer agents efflux.

Keywords: Molecular modeling, P-glycoprotein/ABCB1, MRP4/ABCC4, MRP5/ABCC5, multidrug resistance

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2009
Page: [186 - 193]
Pages: 8
DOI: 10.2174/138955709787316065
Price: $58

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