Solid-Phase Synthesis of Oligosaccharide Drugs: A Review

Author(s): Meenakshi Dhanawat, Sushant Kumar Shrivastava.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 2 , 2009

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Abstract:

Solid- phase synthesis is an approach, where synthetic transformation in carbohydrates are carried out with one of the reactant molecule attached to an insoluble material referred as polymeric support via linker. In recent years, it has been extensively accepted as fast and accurate method for the synthesis of biologically active oligosaccharides. This review attempts to focus on various methods of oligosaccharide synthesis by solid- phase including their applications.

Keywords: Carbohydrate, oligosaccharide, biologically active, solid- phase synthesis, linkers, protecting groups, glycosylating agents

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2009
Page: [169 - 185]
Pages: 17
DOI: 10.2174/138955709787316083
Price: $58

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