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Mini-Reviews in Medicinal Chemistry
ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
VOLUME: 9
ISSUE: 2
DOI: 10.2174/138955709787316056      Price:  $58









Natural Product Inhibitors of Hsp90: Potential Leads for Drug Discovery

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Author(s): M. W. Amolins and B. S.J. Blagg
Pages 140-152 (13)
Abstract:
Heat shock protein 90 has emerged as a promising target for the treatment of cancer and neurodegenerative diseases. This review summarizes recent advancements towards the development of natural products as they pertain to the biological and chemical understanding of this molecular chaperone.
Keywords:
Hsp90, inhibitors, cancer, neurodegenerative diseases, natural products
Affiliation:
Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott 4070, Lawrence, Kansas 66045-7563, USA.