Mini-Reviews in Medicinal Chemistry

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Natural Product Inhibitors of Hsp90: Potential Leads for Drug Discovery

Author(s): M. W. Amolins and B. S.J. Blagg

Affiliation: Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott 4070, Lawrence, Kansas 66045-7563, USA.

Keywords: Hsp90, inhibitors, cancer, neurodegenerative diseases, natural products

Abstract:

Heat shock protein 90 has emerged as a promising target for the treatment of cancer and neurodegenerative diseases. This review summarizes recent advancements towards the development of natural products as they pertain to the biological and chemical understanding of this molecular chaperone.

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Article Details

VOLUME: 9
ISSUE: 2
Page: [140 - 152]
Pages: 13
DOI: 10.2174/138955709787316056