Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL
USA
Email: bdunn@ufl.edu

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Medicinal Plants: A Natural Chaperones Source for Treating Neurological Disorders

Author(s): Bernd Kastenholz and David E. Garfin

Affiliation: Forschungszentrum Julich GmbH, Institut Phytosphare (ICG-3), Julich 52425, Germany.

Abstract:

Currently, no pharmaceuticals for the etiological treatment of neurodegenerative protein-misfolding diseases (e.g., ALS, Alzheimers or prion diseases) are available. In this brief communication the development of chaperone-based medications from medicinal plants (e.g., Ginkgo biloba) are reviewed as referred to specific protein-protein interactions of plant metallochaperones and human enzymes. It is indicated that bioactive copper chaperones for superoxide dismutase isolated from medicinal plants may be lead molecules for drug development in several diseases concerning metal ion metabolisms of man and animals.

Keywords: Metallophytochaperones, blood, Alzheimer's disease, plant extracts, CCS, Ginkgo biloba, SOD, apoenzymes, plant molecular farming, metal ion homeostasis

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Article Details

VOLUME: 16
ISSUE: 2
Page: [116 - 120]
Pages: 5
DOI: 10.2174/092986609787316234
Price: $58