Doripenem: A New Addition to the Carbapenem Class of Antimicrobials
Jason J. Schafer, Debra A. Goff and Julie E. Mangino
Affiliation: UPMC St. Margaret, Department of Pharmacy, 815 Freeport Road, Pittsburgh, PA 15215; USA.
Doripenem (DPM) is the newest antimicrobial in the carbapenem class. It is a broad spectrum agent with activity against gram-positive, gram-negative and anaerobic bacteria. in vitro Susceptibility testing has demonstrated potent activity for many drug resistant gram-negative pathogens including some that are resistant to imipenem and meropenem. It appears to be less likely to induce resistance for certain pathogens compared to the other carbapenems. The purpose of this review is to introduce DPM and describe its potential role in managing infections due to multi-drug resistant gram-negative bacteria. This article also reviews recent patents related to the carbapenem class of antimicrobials.
Keywords: Doripenem, carbapenem, pseudomonas, multi-drug resistant, pharmacodynamics
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