GLP-1 Agonists and Satiety

Author(s): Nicholas T. Bello, Timothy H. Moran.

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued)

Volume 8 , Issue 4 , 2008

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Abstract:

Glucagon-like peptide - 1 (GLP-1, 7-36 amide) is an intestinal hormone that is released in response to the luminal presences of nutrients. GLP-1 and related mimetic drugs are potent stimulators of pancreatic insulin, a response that is beneficial for the management of non-insulin dependent diabetes mellitus. Additional investigations have revealed that GLP-1 is an endocrine mediator of the ileal brake and has direct effects on the neural controls of food intake. The overall mechanism of GLP-1 induced food intake suppression is mediated by distinct, but overlapping, peripheral and central systems. GLP-1 is also expressed in the brain and roles for central GLP-1 in feeding control have been proposed. This review will focus on meal-related GLP-1 release, receptor function, synthetic agonists, and peripheral and central mechanism involved in GLP-1 induced inhibition of food intake.

Keywords: Incretins, exendin-4, aversion, satiety, liraglutide, exenatide, byetta

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Article Details

VOLUME: 8
ISSUE: 4
Year: 2008
Page: [311 - 316]
Pages: 6
DOI: 10.2174/187152208787169170
Price: $58

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