Solution-Phase Parallel Synthesis of N-Arylisoquinuclidines
Ronald F. Borne,
Mark S. Levi,
M. O. Faruk Khan,
Norman H. Wilson.
The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. The presence of the isoquinuclidine ring system in the structure of ibogaine became the lead for the design of a 16-member library of N-aryl isoquinuclidines, where pyridine, pyrimidine and quinoline ring systems were attached directly to the bicyclic nitrogen. A solution-phase method for their synthesis is described.
Keywords: Addiction, Ibogaine, Isoquinuclidine, Parallel synthesis, Anti-addictive
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