Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Antibacterial and Antifungal Activity of 5-Substituted Imidazolones

Author(s): Khalid Mohammed Khan, Uzma Rasool Mughal, Sadia Khan, Saira Khan, Shahnaz Perveen, M. Iqbal Choudhary.


A variety of imidazolones 1-34 derivatives were synthesized and tested for their antibacterial effects against Escherichia coli, Bacillus subtilis, Shigella flexnari, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi. Compound 18 found to be moderately active against S. flexnari, however, compounds 8, 11, 15, 21, 22, 25 showed to be moderate and compounds 31 and 34 exhibited good activities against P. aeruginosa. Compounds 7, 9, 12-14, 24-26, and 29 demonstrated good to excellent activity against S. typhi, while remaining compound did not show significant antibacterial activities. Compounds 7, 9, 12, 13, 14, 25, 26, 29 showed good activities against S. typhi. The antifungal activities of imidazolones were also determined against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani, Candida glabrata and found that compounds showed varying degree of percentage inhibition.

Keywords: Synthesis, Imidazolone, Antifungal, Antibacterial activities

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Article Details

Year: 2009
Page: [69 - 77]
Pages: 9
DOI: 10.2174/157018009787158553