Structural and Morphological Studies of Cationic Liposomes-DNA Complexes

Author(s): Yan Sun, Itziar Migueliz, Gemma Navarro, Conchita Tros de Ilarduya.

Journal Name: Letters in Drug Design & Discovery

Volume 6 , Issue 1 , 2009

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Abstract:

In this study we have prepared and characterized, in terms of structure and morphology, different cationic lipid- DNA complexes (lipoplexes). Condensation studies showing the ability of cationic lipids to condense DNA are presented. The effect of the presence of serum and the ligand transferrin (Tf) has also been evaluated. Studies of negative stain transmission electron microscopy (TEM), infrared spectroscopy (FTIR), differential thermal analysis (DTA) and X-ray diffractometry have shown stable complexes with different morphology and structural rearrangements.

Keywords: Cationic liposomes, Gene delivery, Lipoplexes, Structure, Morphology

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Article Details

VOLUME: 6
ISSUE: 1
Year: 2009
Page: [33 - 37]
Pages: 5
DOI: 10.2174/157018009787158571

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