Abstract
In this study we have prepared and characterized, in terms of structure and morphology, different cationic lipid- DNA complexes (lipoplexes). Condensation studies showing the ability of cationic lipids to condense DNA are presented. The effect of the presence of serum and the ligand transferrin (Tf) has also been evaluated. Studies of negative stain transmission electron microscopy (TEM), infrared spectroscopy (FTIR), differential thermal analysis (DTA) and X-ray diffractometry have shown stable complexes with different morphology and structural rearrangements.
Keywords: Cationic liposomes, Gene delivery, Lipoplexes, Structure, Morphology
Letters in Drug Design & Discovery
Title: Structural and Morphological Studies of Cationic Liposomes-DNA Complexes
Volume: 6 Issue: 1
Author(s): Yan Sun, Itziar Migueliz, Gemma Navarro and Conchita Tros de Ilarduya
Affiliation:
Keywords: Cationic liposomes, Gene delivery, Lipoplexes, Structure, Morphology
Abstract: In this study we have prepared and characterized, in terms of structure and morphology, different cationic lipid- DNA complexes (lipoplexes). Condensation studies showing the ability of cationic lipids to condense DNA are presented. The effect of the presence of serum and the ligand transferrin (Tf) has also been evaluated. Studies of negative stain transmission electron microscopy (TEM), infrared spectroscopy (FTIR), differential thermal analysis (DTA) and X-ray diffractometry have shown stable complexes with different morphology and structural rearrangements.
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Cite this article as:
Sun Yan, Migueliz Itziar, Navarro Gemma and de Ilarduya Tros Conchita, Structural and Morphological Studies of Cationic Liposomes-DNA Complexes, Letters in Drug Design & Discovery 2009; 6 (1) . https://dx.doi.org/10.2174/157018009787158571
DOI https://dx.doi.org/10.2174/157018009787158571 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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