The Anti-Cancer Activity of Noscapine: A Review
Massoud Mahmoudian and Parvaneh Rahimi-Moghaddam
Affiliation: Razi Institute for Drug Research, Department of Pharmacology, College of Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, Iran.
Noscapine is an isoqiunoline alkaloid found in opium latex. Unlike most other alkaloids obtained from opium latex, noscapine is not sedative and has been used as antitussive drug in various countries. Recently, it has been introduced as an anti-mitotic agent. This drug can be used orally .When the resistance to other anti-cancer drugs such as paclitaxel menifests, noscapine might be effective. Therefore, noscapine and its analogs have great potential as novel anticancer agents.
Keywords: Noscapine, antitussive, anti-cancer, anti-mitotic, apoptosis
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