Mini-Reviews in Medicinal Chemistry


Prodrug Designing of NSAIDs

Author(s): Parmeshwari K. Halen, Prashant R. Murumkar, Rajani Giridhar and Mange Ram Yadav

Affiliation: Pharmacy Department, Faculty of Tech.&Engg., Kalabhavan, P. B. No. 51, The M.S.University of Baroda, Vadodara- 390001, India.


Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflammatory diseases suffer from several undesired side effects, the most important being gastrointestinal (GI) irritation and ulceration. The prodrug designing is one of the several strategies used to overcome this drawback. The rationale behind the prodrug concept is to achieve temporary blockade of the free carboxylic group present in the NSAIDs till their systemic absorption. In this paper, a review on the concept of prodrugs designing of NSAIDs to improve their efficacy and reduce the toxicity is being presented.

Keywords: NSAIDs, NO release, amides, esters, inflammation, prodrugs, prostaglandins, ulceration

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Article Details

Page: [124 - 139]
Pages: 16
DOI: 10.2174/138955709787001695