Prodrug Designing of NSAIDs

Author(s): Parmeshwari K. Halen, Prashant R. Murumkar, Rajani Giridhar, Mange Ram Yadav.

Journal Name:Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 1 , 2009

Abstract:

Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflammatory diseases suffer from several undesired side effects, the most important being gastrointestinal (GI) irritation and ulceration. The prodrug designing is one of the several strategies used to overcome this drawback. The rationale behind the prodrug concept is to achieve temporary blockade of the free carboxylic group present in the NSAIDs till their systemic absorption. In this paper, a review on the concept of prodrugs designing of NSAIDs to improve their efficacy and reduce the toxicity is being presented.

Keywords: NSAIDs, NO release, amides, esters, inflammation, prodrugs, prostaglandins, ulceration

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Article Details

VOLUME: 9
ISSUE: 1
Year: 2009
Page: [124 - 139]
Pages: 16
DOI: 10.2174/138955709787001695

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