α-Halogenoacrylic Derivatives of Antitumor Agents

Author(s): Romeo Romagnoli , Pier Giovanni Baraldi , Olga Cruz-Lopez , Carlota Lopez-Cara , Delia Preti .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 1 , 2009

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Abstract:

In this review article we have reported a series of hybrid compounds characterized by the presence of a α- halogenocryloyl alkylating moiety of low chemical reactivity, linked to known antitumor agents or their active moieties. Among them, brostallicin (PNU-166196), was selected for clinical development and is now undergoing Phase II studies in patients with advanced or metastatic soft tissue sarcoma.

Keywords: Antitumor agents, Distamycin A, apoptosis, α-bromoacryloyl, hybrid molecules

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Article Details

VOLUME: 9
ISSUE: 1
Year: 2009
Page: [81 - 94]
Pages: 14
DOI: 10.2174/138955709787001640

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