Oncomirs: From Tumor Biology to Molecularly Targeted Anticancer Strategies

Author(s): Simone Mocellin, Sandro Pasquali, Pierluigi Pilati.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 1 , 2009

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Abstract:

Deregulation of microRNA (miRNA) promotes carcinogenesis, as these molecules can act as oncogenes or tumor suppressor genes. Here we provide an overview of miRNA biology, discuss the most recent findings on miRNA and cancer development/progression, and report on how tumor-related miRNAs (oncomirs) are being used to develop novel cancer specific therapeutic approaches.

Keywords: MicroRNA, miRNA, oncomirs, cancer biology, molecular targets, anticancer therapeutics

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Article Details

VOLUME: 9
ISSUE: 1
Year: 2009
Page: [70 - 80]
Pages: 11
DOI: 10.2174/138955709787001802

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