NF-κB: The Inducible Factors of HIV-1 Transcription and their Inhibitors

Author(s): Yu Mingyan, Liu Xinyong, Erik De Clercq.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 1 , 2009

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Abstract:

NF-kappaB (NF-κB), the transcription factors of HIV-1, play an important role in triggering HIV transcription. The inhibition of NF-κB activation and their signaling pathway offers a potential anti-HIV therapy strategy. This review reports the mode of action of NF-κB in triggering HIV-1 transcription and the status of the inhibitors.

Keywords: AIDS, HIV-1, NF-κB, transcription, inhibitor, LTR, IκB, IKK

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Article Details

VOLUME: 9
ISSUE: 1
Year: 2009
Page: [60 - 69]
Pages: 10
DOI: 10.2174/138955709787001677

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