Synthesis and Biological Evaluation of Novel 6-Deoxy-β -D-Psicofuranosyl Mercaptoheterocyclic Compounds

Author(s): I. G. De Lade, F. G. Braga, R. M. Grazul, E. S. Coimbra, A. D. Da Silva.

Journal Name: Letters in Drug Design & Discovery

Volume 5 , Issue 8 , 2008

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Abstract:

We report herein the synthesis of a series of eight novel compounds based on the coupling of 6-mercaptopurine (4), 2-mercaptopyrimidine (5), 4-mercaptopyridine (6) and 2-mercaptobenzimidazole (7) with 6-deoxy-6-iodo-1,2:3,4-di- O-isopropylidene-γ-D-psicofuranose and subsequent deprotection. The compounds were evaluated in vitro for activity against Leishmania amazonensis and L. chagasi promastigotes and for cytotoxic activity against Kb and Vero cells.

Keywords: D-psicofuranose, 6-mercaptopurine, 2-mercaptopyrimidine, 4-mercaptopyridine, 2-mercaptobenzimidazole

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Article Details

VOLUME: 5
ISSUE: 8
Year: 2008
Page: [481 - 484]
Pages: 4
DOI: 10.2174/157018008786898554
Price: $58

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