Synthesis and Biological Evaluation of Novel 6-Deoxy-β -D-Psicofuranosyl Mercaptoheterocyclic Compounds
I. G. De Lade,
F. G. Braga,
R. M. Grazul,
E. S. Coimbra,
A. D. Da Silva.
We report herein the synthesis of a series of eight novel compounds based on the coupling of 6-mercaptopurine (4), 2-mercaptopyrimidine (5), 4-mercaptopyridine (6) and 2-mercaptobenzimidazole (7) with 6-deoxy-6-iodo-1,2:3,4-di- O-isopropylidene-γ-D-psicofuranose and subsequent deprotection. The compounds were evaluated in vitro for activity against Leishmania amazonensis and L. chagasi promastigotes and for cytotoxic activity against Kb and Vero cells.
Keywords: D-psicofuranose, 6-mercaptopurine, 2-mercaptopyrimidine, 4-mercaptopyridine, 2-mercaptobenzimidazole
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