Generic placeholder image

Inflammation & Allergy - Drug Targets (Discontinued)

Editor-in-Chief

ISSN (Print): 1871-5281
ISSN (Online): 2212-4055

Regulatory T Cells as Targets for Immunotherapy of Autoimmunity and Inflammation

Author(s): Wiebke Hansen, Astrid M. Westendorf and Jan Buer

Volume 7, Issue 4, 2008

Page: [217 - 223] Pages: 7

DOI: 10.2174/187152808786848360

Price: $65

Abstract

Regulatory T (Treg) cells are emerging as key players in the regulation of different immune responses, thereby representing potential candidates for therapeutic interventions in a broad variety of immunological disorders. While the reduction or loss in function would be of benefit during the treatment of cancer, induction and/or expansion of Treg cell function might be helpful to interfere with unwanted immune responses in transplantation medicine, during autoimmunity, allergy and inflammation. However, a better understanding of Treg cell biology is a prerequisite to specifically modulate its function during immune responses in vivo. In the present review we will discuss current concepts on different cell types, components and some novel surface receptors expressed by Treg cells, namely Neuropilin-1, CD83 and G proteincoupled receptor 83 which might represent promising targets for the modulation of Treg cell function in human disease.

Keywords: Regulatory T cells, surface receptor, Foxp3, Neuropilin-1, G protein-coupled receptor 83, CD83


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy