Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157
USA

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Driving Neural Stem Cells Towards a Desired Phenotype

Author(s): Diana Reimers, Rafael Gonzalo-Gobernado, Antonio S. Herranz, Cristina Osuna, Maria J. Asensio, Silvia Baena, Macarena Rodriguez, Eulalia Bazan.

Abstract:

Neural stem cells are defined as clonogenic cells with self-renewal capacity and the ability to generate all neural lineages. Cells with these characteristics have been isolated from the embryonic and adult Central Nervous System. Numerous reports show that extrinsic factors and intracellular mechanisms may trigger both endogenous and in vitro cultured neural stem cells to differentiate into desired cell outcomes. This plasticity opens new approaches for the use of neural stem cells as a source of cells for replacement therapy in damaged brain. In this review we present the evidence for the involvement of trophic factors, neurotransmitters, second messengers, aminoacids, and factors released by endothelial and glial cells, which have been reported to influence neural stem cells phenotypic choice in vitro and in vivo.

Keywords: Neural stem cells, neurogenesis, neurotrophic factors, growth factors, cell replacement therapies, neural regeneration

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Article Details

VOLUME: 3
ISSUE: 4
Year: 2008
Page: [247 - 253]
Pages: 7
DOI: 10.2174/157488808786733980
Price: $58