Antioxidant Therapy in Alzheimers Disease: Theory and Practice

Author(s): Gjumrakch Aliev , Mark E. Obrenovich , V. Prakash Reddy , Justin C. Shenk , Paula I. Moreira , Akihiko Nunomura , Xiongwei Zhu , Mark A. Smith , George Perry .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 13 , 2008

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Alzheimer disease treatment has yet to yield a successful therapy that addresses the source of the damage found in brains. Of the varied proposed theories of AD etiology, reactive oxygen species (ROS) generation is cited as a common factor. Efforts to reduce the pathology associated with ROS via antioxidants therefore offer new hope to patients suffering from this devastative disease.

Keywords: Antioxidant, calorie restriction, estrogen, free radical, glutathione, oxidation, oxidative stress, therapy

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Article Details

Year: 2008
Page: [1395 - 1406]
Pages: 12
DOI: 10.2174/138955708786369582
Price: $58

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