Mini-Reviews in Medicinal Chemistry

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Antioxidant Therapy in Alzheimers Disease: Theory and Practice

Author(s): Gjumrakch Aliev, Mark E. Obrenovich, V. Prakash Reddy, Justin C. Shenk, Paula I. Moreira, Akihiko Nunomura, Xiongwei Zhu, Mark A. Smith and George Perry

Affiliation: College of Sciences, University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas, 78249, USA.

Keywords: Antioxidant, calorie restriction, estrogen, free radical, glutathione, oxidation, oxidative stress, therapy

Abstract:

Alzheimer disease treatment has yet to yield a successful therapy that addresses the source of the damage found in brains. Of the varied proposed theories of AD etiology, reactive oxygen species (ROS) generation is cited as a common factor. Efforts to reduce the pathology associated with ROS via antioxidants therefore offer new hope to patients suffering from this devastative disease.

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Article Details

VOLUME: 8
ISSUE: 13
Page: [1395 - 1406]
Pages: 12
DOI: 10.2174/138955708786369582