Mini-Reviews in Medicinal Chemistry

Back

Suramin: Clinical Uses and Structure-Activity Relationships

Author(s): Ross P. McGeary, Andrew J. Bennett, Quoc B. Tran, Kelly L. Cosgrove, Benjamin P. Ross.

Abstract:

Suramin is a polysulfonated polyaromatic symmetrical urea. It is currently used to treat African river blindness and African sleeping sickness. Suramin has also been extensively trialed recently to treat a number of other diseases, including many cancers. Here, we examine its modes of action and discuss its structure-activity relationships.

Keywords: Suramin, trypanosomiasis, onchocerciasis, FGF

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 8
ISSUE: 13
Year: 2008
Page: [1384 - 1394]
Pages: 11
DOI: 10.2174/138955708786369573
Price: $58