Bradykinin B1 Receptor Antagonists as Novel Analgesics: A Retrospective of Selected Medicinal Chemistry Developments

Author(s): Scott D. Kuduk, Mark G. Bock.

Journal Name: Current Topics in Medicinal Chemistry

Volume 8 , Issue 16 , 2008

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Bradykinin B1 receptor antagonists embody a potentially novel approach for the treatment of chronic pain and inflammation. The identification of non-peptide B1 antagonists has been a notable advance in the kinin field that will allow evaluation of their therapeutic potential in the clinical realm. The current review is a high level summary of our contributions to the area that culminated in the discovery of a clinical candidate.

Keywords: Analgesics, pain, inflammation, bradykinin, covalent binding, P-glycoprotein

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Article Details

Year: 2008
Page: [1420 - 1430]
Pages: 11
DOI: 10.2174/156802608786264263
Price: $58

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