A Review of Surrogate Markers for Atherosclerosis: Flow Mediated Dilatation; Carotid Intima Media Thickness; Pulse Wave Velocity; Ankle Brachial Index

Author(s): Kai-Hang Yiu, Kui-Kai Lau, Chu-Pak Lau, Hung-Fat Tse.

Journal Name: Vascular Disease Prevention

Volume 5 , Issue 4 , 2008

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Abstract:

Atherosclerotic disease is a major cause of morbidity and mortality. The early detection of preclinical atherosclerosis with non-invasive tools has become paramount in order to identify the vulnerable patient and provide aggressive prevention measures. A valid surrogate marker should not only be proven to correlate with underlying atherosclerosis but also needs to be accurate, reproducible and inexpensive. There are currently a number of methods that are widely used for the detection of preclinical atherosclerosis. In this review, we chose 4 methods for discussion namely, (1) Flow-mediated dilatation, (2) Carotid intima media thickness, (3) Pulse wave velocity, and, (4) Ankle brachial index. Clinical evidence concerning their detection of underlying atherosclerosis and their predictive value of cardiovascular events together with their individual drawbacks is discussed.

Keywords: Atherosclerosis, surrogate marker, flow-mediated dilatation, carotid intima-media thickness, pulse wave velocity, ankle brachial index

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2008
Page: [234 - 245]
Pages: 12
DOI: 10.2174/1567270010805040234
Price: $58

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