Medicinal Chemistry

Atta-ur-Rahman  
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: mc@benthamscience.org

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A Comparison of the Biological Properties of Small Molecular Weight Agonists and Antagonists of CD200:CD200R Interactions

Author(s): Reg Gorczynski, Ivo Boudakov and Ismat Khatri

Affiliation: Rm.2-805, MaRS Tower, The Toronto Hospital, 101 College Street, Toronto Ontario, M5G1L7, Canada.

Abstract:

Our laboratory and others have documented in some detail the immunological consequences which follow from interaction of the ubiquitously expressed molecule CD200 with its receptor(s) CD200R (expressed predominantly on cells of myeloid and lymphoid origin). In particular, there is evidence that these interactions lead to immunosuppressive signals which modulate graft rejection responses; decrease the manifestations of arthritis in rodent models; diminish mast cell mediator release in models of allergic disease; and favour the growth of tumors in both mice and humans. The development of small molecular weight agonists (and/or antagonists) of these interactions would thus likely have significant clinical importance. The data reported herein characterizes several such molecules in a number of rodent models.

Keywords: Tolerance, immunosuppression, inflammation, immunoglobulin superfamily

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Article Details

VOLUME: 4
ISSUE: 6
Page: [624 - 631]
Pages: 8
DOI: 10.2174/157340608786241981
Price: $58