The Exploding Field of the HCV Polymerase Non-Nucleoside Inhibitors: Summary of a First Generation Compounds

Author(s): Enzo Tramontano.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 12 , 2008

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Abstract:

The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) is strictly essential for viral replication and it has been used as viral target for anti-HCV drug development. All small molecules which have been identified to be selective non-nucleoside inhibitors (NNI) of the HCV RdRp to date are reported.

Keywords: HCV, RNA dependent RNA polymerase (RdRp), non-nucleoside, inhibition, drug development, antiviral, NNI, small molecules

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Article Details

VOLUME: 8
ISSUE: 12
Year: 2008
Page: [1298 - 1310]
Pages: 13
DOI: 10.2174/138955708786141061
Price: $58

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