Synthesis of Marine Natural Products with Antimalarial Activity

Author(s): Ines Mancini, Graziano Guella, Andrea Defant.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 12 , 2008

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Abstract:

The role played by synthetic organic chemistry of marine metabolites as potential leads for drug discovery of antimalarial agents is discussed. Syntheses of the most promising molecules are summarized, with emphasis on structureactivity relationship (SAR) studies and their mechanism of action.

Keywords: Natural products, marine metabolites, drug discovery, synthesis, retrosynthetic analysis, antiprotozoal, antimalarial, antiplasmodial

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Article Details

VOLUME: 8
ISSUE: 12
Year: 2008
Page: [1265 - 1284]
Pages: 20
DOI: 10.2174/138955708786141007
Price: $58

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