Recent Advances in the Research of HIV-1 RNase H Inhibitors

Author(s): Fang Yu , Xinyong Liu , Peng Zhan , Erik De Clercq .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 8 , Issue 12 , 2008

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Reverse transcription is a crucial step in the life cycle of human immunodeficiency virus type 1 (HIV-1). In this process, multiple functional enzymes including RNA-dependent DNA polymerase, DNA-dependent DNA polymerase and RNase H are indispensable. The RNase H functions to degrade RNA of the RNA – DNA heteroduplex into small fragment. These properties of HIV-1 RNase H make it an attractive target for rational anti-HIV-1 drug design and development. In this review, we summarized the HIV-1 RNase H inhibitors that were recently reported in the literature, including their chemical structure, mechanism and structure-activity relationship. It seems likely that HIV-1 RNase H as a prominent non-traditional target may lead to the development of anti-HIV agents which could be used alone or in the combination with other HIV inhibitors in AIDS chemotherapy.

Keywords: HIV-1, AIDS, RNase H inhibitor, mechanism, SAR

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Article Details

Year: 2008
Page: [1243 - 1251]
Pages: 9
DOI: 10.2174/138955708786141052
Price: $58

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